Protein MMP15* map

Identifiers
matrix metallopeptidase 15 (membrane-inserted)
"matrix metalloproteinase 15 (membrane-inserted)"
HUGO:MMP15 HGNC:7161 ENTREZ:4324 UNIPROT:P51511

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

MMP15*@Extracellular space

References
em_emtc_emtc_re1586( EMT Senescence  map ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.

Modifications:
In compartment: Extracellular space
  1. MMP15*@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP15@Extracellular space map → map MMP15*@Extracellular space map
    As Catalyser:
    1. MMP2@Extracellular space map → map MMP2*@Extracellular space map