Identifiers
Rac1_GAPs*
Rho GTPase activating protein 1
HUGO:ARHGAP1, HGNC:673, ENTREZ:392, GENECARDS:GC11M046698, UNIPROT:Q07960
Rho GTPase activating protein 9
HUGO:ARHGAP9 HGNC:14130 ENTREZ:64333 UNIPROT:Q9BRR9
Rho GTPase activating protein 12
HUGO:ARHGAP12 HGNC:16348 ENTREZ:94134 UNIPROT:Q8IWW6
SLIT-ROBO Rho GTPase activating protein 3
"SLIT-ROBO Rho GTPase activating protein 2", SRGAP2
HUGO:SRGAP3 HGNC:19744 ENTREZ:9901 UNIPROT:O43295
Rho GTPase activating protein 24
HUGO:ARHGAP24 HGNC:25361 ENTREZ:83478 UNIPROT:Q8N264
Rho GTPase activating protein 32
HUGO:ARHGAP32, HGNC:17399, ENTREZ:9743, GENECARDS:GC11M128834, UNIPROT:A7KAX9
breakpoint cluster region
BCR1, D22S11
HUGO:BCR HGNC:1014 ENTREZ:613 UNIPROT:P11274
ralA binding protein 1
HUGO:RALBP1 HGNC:9841 ENTREZ:10928 UNIPROT:Q15311
active BCR-related
"active BCR-related gene"
HUGO:ABR HGNC:81 ENTREZ:29 UNIPROT:Q12979
chimerin 2
"chimerin (chimaerin) 2"
HUGO:CHN2 HGNC:1944 ENTREZ:1124 UNIPROT:P52757
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
em_emtc_emtc_re757( EMT Senescence ):
PMID:25234227
Upon recruitment, NDPK promotes endocytic vesicle fission and downstream inactivation of Rac1
em_emtc_emtc_re836( EMT Senescence ):
Cross-talk between small GTPase signaling pathways.
PMID:12134164
PMID:7673236
HRAS activates TIAM1 which is a GEF for Rac1.
RalBP1 (which is an effector for RalA and RalB) inactivates Rac1
→ ARHGAP14*@Cytosol
→ ARHGAP12@Cytosol
→ ARHGAP9@Cytosol
→ BCR@Cytosol
→ ARHGAP1@Cytosol
→ RALBP1@Cytosol
→ ABR@Cytosol
→ CHN2@Cytosol
→ ARHGAP24@Cytosol
→ ARHGAP32|Y_pho@Cytosol
→ RACGAP1@Cytosol