Identifiers
HGNC:3763
HUGO:FLT1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity   / MARKERS_MDSC 
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 

References
PMID:16076871
 DENDRITIC_CELL 
 MDSC 
CASCADE:VEGFA
PMID:16002046, PMID:9570538
Inhibitory function of VEGF on DC function is most likely mediated by Flt-1.
PMID:16002046
Id1???/??? DCs did not respond to the VEGF stimulus because of defective Flt-1 signaling in these mutant mice. Thus, Flt-1 seems to be an important player in VEGF???DC interactions.

References
an_re8:( Angiogenesis  ) PMID:25922287

1. FLT1@Cytosol

1. FLT1@INNATE_IMMUNE_CELL_Membrane

1. FLT1@MARKERS_MDSC

1. FLT1@Membrane

1. FLT1:​NRP1:​PGF@Cytosol
2. FLT1:​NRP1:​VEGFAb* @Cytosol
3. FLT1:​NRP1:​VEGFA:​VEGFB@Cytosol

1. FLT1:​VEGFA@INNATE_IMMUNE_CELL_Membrane

1. FLT1:​VEGF*@Membrane

1. PGF@Extracellular Matrix + NRP1@Extracellular Matrix + FLT1@Cytosol → FLT1:​NRP1:​PGF@Cytosol
2. FLT1:​NRP1:​VEGFA:​VEGFB@Cytosol → FAK*@Cytosol
3. VEGFAb* @Extracellular Matrix + FLT1@Cytosol + NRP1@Extracellular Matrix → FLT1:​NRP1:​VEGFAb* @Cytosol
4. VEGFA:​VEGFB@Extracellular Matrix + NRP1@Extracellular Matrix + FLT1@Cytosol → FLT1:​NRP1:​VEGFA:​VEGFB@Cytosol
5. VEGFA@default + FLT1@INNATE_IMMUNE_CELL_Membrane → FLT1:​VEGFA@INNATE_IMMUNE_CELL_Membrane
6. rFLT1@INNATE_IMMUNE_CELL_Cytosol → FLT1@INNATE_IMMUNE_CELL_Membrane
7. VEGF*@Membrane + FLT1@Membrane → FLT1:​VEGF*@Membrane
8. FLT1:​VEGF*@Membrane → PLCG_PATHWAYS@Membrane
9. FLT1:​VEGF*@Membrane → PI3K_PATHWAY@Membrane

1. Quiescence of vasculature@Cytosol → Angiogenesis@Cytosol
2. PLCG1@Cytosol → PLCG1|​pho@Cytosol
3. GRB2@Cytosol + SOS*@Cytosol + SHC1@Cytosol → GRB2:​SHC1:​SOS*@Cytosol
4. ID1@INNATE_IMMUNE_CELL_Cytosol → ID1@INNATE_IMMUNE_CELL_Cytosol