Identifiers
sprouty homolog 1 antagonist of FGF signaling (Drosophila)
"sprouty (Drosophila) homolog 1 (antagonist of FGF signaling)"
HUGO:SPRY1 HGNC:11269 ENTREZ:10252 UNIPROT:O43609
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
su_mpk1_mpk1_re288( Survival ):
Sprouty is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:15173823
References
su_mpk1_mpk1_re288( Survival ):
Sprouty is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:15173823
su_mpk1_mpk1_re9( Survival ):
Sos mediates Ras activation. Interaction of Sos with Ras induces the formation of RasGTP from RasGDP.
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:17496910 PMID:15173823
su_mpk1_mpk1_re273( Survival ):
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR).
PMID:11447289 PMID:11997436 PMID:15173823