Protein RAP1A map

Identifiers
RAP1A, member of RAS oncogene family
HUGO:RAP1A, HGNC:9855, ENTREZ:5906, UNIPROT:P62834, GENECARDS:RAP1A
HUGO:RAP1A

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
Reviews
PMID:18680434, PMID;PMID:16166375, PMID:19965504
Identification of RAP1A
PMID:10850490
 NATURAL_KILLER  map
CASCADE:NKG2D
PMID:19454690
Ligation of either the FcR or NKG2D results in activation of Rap1and induces Rap1-RAPL-MST1 signaling cascade.
Rap1 is activated following FcR and NKG2D ligation in a PI3K- and CrkL-dependent manner.
Rap1 regulates NKG2D-mediated adhesion and MTOC polarization leading to NK cell cytotoxicity.

RAP1A@Nucleus

References
te_re7:( Telomere Maintenance  map ) PMID:18680434

Modifications:
In compartment: Nucleus
  1. RAP1A@Nucleus map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. POT1:​RAP1A:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
  2. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TPP1:​Telomeric_DNA*@Nucleus map
  3. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
  4. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Uncoiled_telomeric_DNA*@Nucleus map
  5. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2|​ubi:​TPP1:​Telomeric_DNA*@Nucleus map
  6. POT1:​RAP1A:​TERF1*|​unk|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map → map Conjugate_formation@INNATE_IMMUNE_CELL_Membrane map
  3. CBX3@Nucleus map → map POT1:​RAP1A:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
  4. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map POT1:​RAP1A:​TERF1*|​unk|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
  5. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2|​ubi:​TPP1:​Telomeric_DNA*@Nucleus map
  6. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map DNA repair@Nucleus map
  7. POT1:​RAP1A:​TERF1*|​unk|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map TERF1*|​unk|​hm2@Nucleus map + POT1:​RAP1A:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
  8. POT1:​RAP1A:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map Telomerase recruitment@Nucleus map
  9. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2|​ubi:​TPP1:​Telomeric_DNA*@Nucleus map → map TINF2|​ubi@Nucleus map + POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TPP1:​Telomeric_DNA*@Nucleus map
  10. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map HR@Nucleus map
  11. POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map → map POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Uncoiled_telomeric_DNA*@Nucleus map
  12. RAP1A@Nucleus map + TINF2@Nucleus map + TERF2|​hm2@Nucleus map + TPP1@Nucleus map + gTelomeric_DNA*@Nucleus map + TERF1*|​hm2@Nucleus map + POT1@Nucleus map → map POT1:​RAP1A:​TERF1*|​hm2:​TERF2|​hm2:​TINF2:​TPP1:​Telomeric_DNA*@Nucleus map
As Catalyser:
  1. RASSF5@INNATE_IMMUNE_CELL_Cytosol map + MST1@INNATE_IMMUNE_CELL_Cytosol map → map MST1|​pho:​RASSF5@INNATE_IMMUNE_CELL_Cytosol map
  2. Nucleotides@Nucleus map → map gTelomeric G-Strand@Nucleus map