Gene DUSP1 map

Identifiers
HUGO:DUSP1
dual specificity phosphatase 1
PTPN10
HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:23124025, PMID:16184516
IL13 induces DUSP1 expression via TYK2 and probably STAT6
In silico??analysis identified a STAT6 binding site at position +99 (relative to the transcriptional start site) of the mouse DUSP1 promoter.??
PMID:16184516
IL-10 induces the expression of DUSP1, which negatively regulates p38 phosphorylation and thus limits IL-10 production

gDUSP1@INNATE_IMMUNE_CELL_Cytosol

References
in_re1117( Innate Immunity  map ):
PMID:23124025
IL13 induces DUSP1 expression via TYK2 and probably STAT6

gDUSP1@Nucleus

References
su_mpk1_mpk1_re201( Survival  map ):
CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13).
PMID:19815709
su_mpk1_mpk1_re221:( Survival  map ) Translation

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gDUSP1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. gDUSP1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gDUSP1@INNATE_IMMUNE_CELL_Cytosol map → map rDUSP1@INNATE_IMMUNE_CELL_Cytosol map
    2. CREB1|​pho@Nucleus map → map gDUSP1@Nucleus map
    3. gDUSP1@Nucleus map → map DUSP1@Nucleus map
    As Catalyser: