Identifiers
HUGO:STAT3
signal transducer and activator of transcription 3
HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 GENECARDS:STAT3 REACTOME:403956 KEGG:6774 ATLASONC:STAT3ID444 WIKI:STAT3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / HEDGEHOG 

References
 MACROPHAGE 
 NEUTROPHIL 
 MDSC 
 DENDRITIC_CELL 
CASCADE:IL10
CASCADE:FLT3LG
CASCADE:IFNAB
PMID:21383238
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
miR-17-5p and miR-20a also reduced the transcriptional and protein levels of p47phox and gp91phox, two subunits of NADPH oxidase.
PMID:19424782

References
s_shh2_re152:( Survival  ) PMID:21383238

1. rSTAT3@INNATE_IMMUNE_CELL_Cytosol

1. rSTAT3@Nucleus

1. MIR17:​STAT3@INNATE_IMMUNE_CELL_Cytosol
2. MIR20A:​STAT3@INNATE_IMMUNE_CELL_Cytosol

1. MIR20A:​STAT3@Nucleus
2. MIR17-5P*:​STAT3@Nucleus

1. gSTAT3@INNATE_IMMUNE_CELL_Cytosol → rSTAT3@INNATE_IMMUNE_CELL_Cytosol
2. rSTAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3@INNATE_IMMUNE_CELL_Cytosol
3. gSTAT3@INNATE_IMMUNE_CELL_Cytosol → rSTAT3@INNATE_IMMUNE_CELL_Cytosol
4. rSTAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3@INNATE_IMMUNE_CELL_Cytosol
5. rSTAT3@INNATE_IMMUNE_CELL_Cytosol + arMIR20A@INNATE_IMMUNE_CELL_Cytosol → MIR20A:​STAT3@INNATE_IMMUNE_CELL_Cytosol
6. rSTAT3@INNATE_IMMUNE_CELL_Cytosol + arMIR17@INNATE_IMMUNE_CELL_Cytosol → MIR17:​STAT3@INNATE_IMMUNE_CELL_Cytosol
7. MIR20A:​STAT3@INNATE_IMMUNE_CELL_Cytosol → degraded
8. MIR17:​STAT3@INNATE_IMMUNE_CELL_Cytosol → degraded
9. arMIR17-5P*@Nucleus + rSTAT3@Nucleus → MIR17-5P*:​STAT3@Nucleus
10. arMIR20A@Nucleus + rSTAT3@Nucleus → MIR20A:​STAT3@Nucleus