ZO1_2_3*

Protein ZO1_2_3*

Identifiers
ZO1_2_3*
tight junction protein 1
HUGO:TJP1, HGNC:11827, ENTREZ:7082, GENECARDS:GC15M029991, UNIPROT:Q07157??
tight junction protein 2
HUGO:TJP2, HGNC:11828, ENTREZ:9414, GENECARDS:GC09P071766, UNIPROT:Q9UDY2??
tight junction protein 3
HUGO:TJP3, HGNC:11829, ENTREZ:27134, GENECARDS:GC19P003659, UNIPROT:O95049

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS

ZO1_2_3*@Cytosol

References
em_emtc_emtc_re499( EMT Senescence ):
PMID:10613913
Cingulin is a functionally important component of TJ.
It interacts with ZO-1, ZO-2, ZO-3, and myosin thus links the submembrane plaque domain of TJ to the actomyosin cytoskeleton
em_emtc_emtc_re667( EMT Senescence ):
PMID:19418635
GJD2 is widely expressed in neurons and was previously shown to interact with the PDZ domain-containing protein ZO-1.
Direct association of connexin36 (GJD2) with ZO-2 and ZO-3 was also demonstrated.
PMID:15558297
Association of connexin36 with ZO-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
The functional significance of Cx36/ZO-1 interaction remains to be established
Interestingly, ZO-1 was not associated with Cx36 intracellularly, suggesting that functions of its interaction with at least Cx36 may be restricted to intact gap junctions at plasma membranes.
PMID:16650609
Association of connexin36 and ZO-1 with ZO-2 and the transcription factor ZO-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina.
PMID:17681699
In the outer plexiform layer of mouse retina, ZO-1 interacts with connexin36 but not with Cx57, and there is an absence of connexin57/connexin36 heterotypic gap junctional coupling in mouse retina

Modifications:
In compartment: Cytosol

ZO1_2_3*@Cytosol

Participates in complexes:
In compartment: Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: