Protein TNC map

Identifiers
tenascin C
HUGO:TNC hgnc_id:HGNC:5318 HGNC:5318 ENTREZ:3371 UNIPROT:P24821

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / FIBROBLAST_ACTIVATION_MARKERS  map

References
CASCADE:TGFB
PMID:16572188
Fibroblasts can acquire an activated phenotype, which is associated with an increased proliferative activity and enhanced secretion of ECM proteins such as type I collagen and tenascin C, and also fibronectin that contains the extra domain a (EDA-fibronectin) and SPARC (secreted protein acidic and rich in cysteine). Phenotypically, activated fibroblasts are often characterized as expressing -smooth-muscle actin. Numerous growth factors such as transforming growth factor- (TGF), chemokines such as monocyte chemotactic protein 1 (MCP1), and ECM-degrading proteases have been shown to mediate the activation of fibroblasts.
PMID:20833777
Tenascin-C deficiency attenuates TGF-??-mediated fibrosis ans decrease protein level of collagen and aSMA in fibroblasts
PMID:15059978
Proinvasive factors secreted by myofibroblasts are identified as TNC and SF/HGF, each of
which is necessary but not sufficient for stimulation of invasion of human colon cancer cells

Modifications:
In compartment: Cytosol
  1. TNC@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TNC@Cytosol map → map MARKERS_OF_FIBROBLAST_ACTIVATION@default map
    2. rTNC@Cytosol map → map TNC@Cytosol map
    3. TNC@Cytosol map → map Fibrosis@default map
    As Catalyser:
    1. rCollagens*@Cytosol map → map Collagens*@Cytosol map
    2. rACTA2@Cytosol map → map ACTA2@Cytosol map