Identifiers
actin, alpha 2, smooth muscle, aorta
HUGO:ACTA2 hgnc_id:HGNC:130 HGNC:130 ENTREZ:59 UNIPROT:P62736
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / FIBROBLAST_ACTIVATION_MARKERS
Cancer Associated Fibroblasts / MOTILITY
References
CASCADE:TGFB
CASCADE:INTEGRIN
CASCADE:HGF
CASCADE:HH
PMID:21674557
Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts.
This effect is mediated by up-regulation of specific genes related to a myo/contractile phenotype (ACTA2, CNN1,FN (ED-A containing), EDN1, MYL12A, TAGLN2) and inhibition of ACTG2 expression.
PMID:19747910, PMID:8515656
Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion and migration of the cancer cells. We report that TGF-beta and IL-1beta are important factors in inducing differentiation of myofibroblasts and expression of functional markers, notably alpha-SMA.
PMID:27111285
ILK/AKT pathway probably mediates TGF-??1-induced ??-SMA expression and myofibroblast differentiation
PMID:23673986
??-SMA expression in CAFs is a negative factor for patient survival.
PMID:20129924
human corneal fibroblasts were transfected with small interfering RNA to alpha11, which decreased alpha-smooth muscle actin expression and myofibroblast differentiation
PMID:11553712
Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.
PMID:23402812
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
HGF induces expression markers of activated fibroblasts such as FAP, CXCL12 (SDF1),aplpha-SMA
→ MARKERS_OF_FIBROBLAST_ACTIVATION@default
→ ECM_REGULATION@default
→ Actin cytoskeletal*@Cytosol
→ FIBROBLAST_MARKERS@default
→ ACTA2@Cytosol