Identifiers
collagen type I alpha 1 chain
HUGO:COL1A1 hgnc_id:HGNC:2197 HGNC:2197 ENTREZ:1277 UNIPROT:P02452
collagen type I alpha 2 chain
HUGO:COL1A2 hgnc_id:HGNC:2198 HGNC:2198 ENTREZ:1278 UNIPROT:P08123
collagen type II alpha 1 chain
HUGO:COL2A1 hgnc_id:HGNC:2200 HGNC:2200 ENTREZ:1280 UNIPROT:P02458
collagen type III alpha 1 chain
HUGO:COL3A1 hgnc_id:HGNC:2201 HGNC:2201 ENTREZ:1281 UNIPROT:P02461
collagen type IV alpha 1 chain
HUGO:COL4A1 hgnc_id:HGNC:2202 HGNC:2202 ENTREZ:1282 UNIPROT:P02462
collagen type IV alpha 2 chain
HUGO:COL4A2 hgnc_id:HGNC:2203 HGNC:2203 ENTREZ:1284 UNIPROT:P08572
collagen type IV alpha 3 chain
HUGO:COL4A3 hgnc_id:HGNC:2204 HGNC:2204 ENTREZ:1285 UNIPROT:Q01955
collagen type IV alpha 4 chain
HUGO:COL4A4 hgnc_id:HGNC:2206 HGNC:2206 ENTREZ:1286 UNIPROT:P53420
collagen type IV alpha 5 chain
HUGO:COL4A5 hgnc_id:HGNC:2207 HGNC:2207 ENTREZ:1287 UNIPROT:P29400
collagen type IV alpha 6 chain
HUGO:COL4A6 hgnc_id:HGNC:2208 HGNC:2208 ENTREZ:1288 UNIPROT:Q14031
collagen type V alpha 1 chain
HUGO:COL5A1 hgnc_id:HGNC:2209 HGNC:2209 ENTREZ:1289 UNIPROT:P20908
collagen type V alpha 2 chain
HUGO:COL5A2 hgnc_id:HGNC:2210 HGNC:2210 ENTREZ:1290 UNIPROT:P05997
collagen type V alpha 3 chain
HUGO:COL5A3 hgnc_id:HGNC:14864 HGNC:14864 ENTREZ:50509 UNIPROT:P25940
collagen type VI alpha 1 chain
HUGO:COL6A1 hgnc_id:HGNC:2211 HGNC:2211 ENTREZ:1291 UNIPROT:P12109
collagen type VI alpha 2 chain
HUGO:COL6A2 hgnc_id:HGNC:2212 HGNC:2212 ENTREZ:1292 UNIPROT:P12110
collagen type VI alpha 3 chain
HUGO:COL6A3 hgnc_id:HGNC:2213 HGNC:2213 ENTREZ:1293 UNIPROT:P12111
collagen type VI alpha 4 pseudogene 1
HUGO:COL6A4P1 hgnc_id:HGNC:33484 HGNC:33484 ENTREZ:344875
collagen type VI alpha 4 pseudogene 2
HUGO:COL6A4P2 hgnc_id:HGNC:38501 HGNC:38501 ENTREZ:646300
collagen type VI alpha 5 chain
HUGO:COL6A5 hgnc_id:HGNC:26674 HGNC:26674 ENTREZ:256076 UNIPROT:A8TX70
collagen type VI alpha 6 chain
HUGO:COL6A6 hgnc_id:HGNC:27023 HGNC:27023 ENTREZ:131873 UNIPROT:A6NMZ7
collagen type VII alpha 1 chain
HUGO:COL7A1 hgnc_id:HGNC:2214 HGNC:2214 ENTREZ:1294 UNIPROT:Q02388
collagen type VIII alpha 1 chain
HUGO:COL8A1 hgnc_id:HGNC:2215 HGNC:2215 ENTREZ:1295 UNIPROT:P27658
collagen type VIII alpha 2 chain
HUGO:COL8A2 hgnc_id:HGNC:2216 HGNC:2216 ENTREZ:1296 UNIPROT:P25067
collagen type IX alpha 1 chain
HUGO:COL9A1 hgnc_id:HGNC:2217 HGNC:2217 ENTREZ:1297 UNIPROT:P20849
collagen type IX alpha 2 chain
HUGO:COL9A2 hgnc_id:HGNC:2218 HGNC:2218 ENTREZ:1298 UNIPROT:Q14055
collagen type IX alpha 3 chain
HUGO:COL9A3 hgnc_id:HGNC:2219 HGNC:2219 ENTREZ:1299 UNIPROT:Q14050
collagen type X alpha 1 chain
HUGO:COL10A1 hgnc_id:HGNC:2185 HGNC:2185 ENTREZ:1300 UNIPROT:Q03692
collagen type XI alpha 1 chain
HUGO:COL11A1 hgnc_id:HGNC:2186 HGNC:2186 ENTREZ:1301 UNIPROT:P12107
collagen type XI alpha 2 chain
HUGO:COL11A2 hgnc_id:HGNC:2187 HGNC:2187 ENTREZ:1302 UNIPROT:P13942
collagen type XII alpha 1 chain
HUGO:COL12A1 hgnc_id:HGNC:2188 HGNC:2188 ENTREZ:1303 UNIPROT:Q99715
collagen type XIII alpha 1 chain
HUGO:COL13A1 hgnc_id:HGNC:2190 HGNC:2190 ENTREZ:1305 UNIPROT:Q5TAT6
collagen type XIV alpha 1 chain
HUGO:COL14A1 hgnc_id:HGNC:2191 HGNC:2191 ENTREZ:7373 UNIPROT:Q05707
collagen type XV alpha 1 chain
HUGO:COL15A1 hgnc_id:HGNC:2192 HGNC:2192 ENTREZ:1306 UNIPROT:P39059
collagen type XVI alpha 1 chain
HUGO:COL16A1 hgnc_id:HGNC:2193 HGNC:2193 ENTREZ:1307 UNIPROT:Q07092
collagen type XVII alpha 1 chain
HUGO:COL17A1 hgnc_id:HGNC:2194 HGNC:2194 ENTREZ:1308 UNIPROT:Q9UMD9
collagen type XVIII alpha 1 chain
HUGO:COL18A1 hgnc_id:HGNC:2195 HGNC:2195 ENTREZ:80781 UNIPROT:P39060
collagen type XIX alpha 1 chain
HUGO:COL19A1 hgnc_id:HGNC:2196 HGNC:2196 ENTREZ:1310 UNIPROT:Q14993
collagen type XX alpha 1 chain
HUGO:COL20A1 hgnc_id:HGNC:14670 HGNC:14670 ENTREZ:57642 UNIPROT:Q9P218
collagen type XXI alpha 1 chain
HUGO:COL21A1 hgnc_id:HGNC:17025 HGNC:17025 ENTREZ:81578 UNIPROT:Q96P44
collagen type XXII alpha 1 chain
HUGO:COL22A1 hgnc_id:HGNC:22989 HGNC:22989 ENTREZ:169044 UNIPROT:Q8NFW1
collagen type XXIII alpha 1 chain
HUGO:COL23A1 hgnc_id:HGNC:22990 HGNC:22990 ENTREZ:91522 UNIPROT:Q86Y22
collagen type XXIV alpha 1 chain
HUGO:COL24A1 hgnc_id:HGNC:20821 HGNC:20821 ENTREZ:255631 UNIPROT:Q17RW2
collagen type XXV alpha 1 chain
HUGO:COL25A1 hgnc_id:HGNC:18603 HGNC:18603 ENTREZ:84570 UNIPROT:Q9BXS0
collagen type XXVI alpha 1 chain
HUGO:COL26A1 hgnc_id:HGNC:18038 HGNC:18038 ENTREZ:136227 UNIPROT:Q96A83
collagen type XXVII alpha 1 chain
HUGO:COL27A1 hgnc_id:HGNC:22986 HGNC:22986 ENTREZ:85301 UNIPROT:Q8IZC6
collagen type XXVIII alpha 1 chain
HUGO:COL28A1 hgnc_id:HGNC:22442 HGNC:22442 ENTREZ:340267 UNIPROT:Q2UY09
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
References
CASCADE:TGFB
CASCADE:IFNG
CASCADE:INTERGIN
CASCADE:IGF1R
CASCADE:HH
PMID:16572188
Fibroblasts synthesize many of the constituents of the fibrillar ECM such as type I (genes COL1A1, COL1A2), type III (COL3A1) and type V collagen (COL5A1, COL5A2, COL5A3), and fibronectin.
They also contribute to the formation of basement membranes by secreting type IV collagen (COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6) and laminin.
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collagen type I, which is known to be secreted by activated fibroblasts, can promote infiltration of immune cells. However it also inhibits the ability of macrophages to kill cancer cells by affecting their polarization into an immunosuppressive phenotype.
PMID:11279127
Dominant-Negative Smad3 and Inhibitory Smad7 Expression Block TGF-??-induced ECM Promoter Activation in fibroblasts
COL1A2, COL3A1, COL6A1, COL6A3, and TIMP-1
PMID:9456329;PMID:11112697
Integrin ??2??1 is a heterodimeric adhesive protein receptor belonging to the ??1 subfamily. It serves as a collagen receptor on fibroblasts and platelets and additionally as a laminin receptor on epithelial and endothelial cells
PMID:19397781
collagens are ligands for a1b1, a2b1 and a11b1 integrins in CAFs
PMID:24856586
Myofibroblast Depletion Reduced Type I Collagen Content and Altered Extracellular Matrix Organization in PDAC.
These results are consistent with the ability of ??SMA+ myofibroblasts to produce type I collagen and induce fibrosis in PDAC.