Protein GADD45* map

Identifiers
growth arrest and DNA-damage-inducible alpha
DDIT1
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522
growth arrest and DNA-damage-inducible beta
MYD118
HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
Expression of GADD45 is the culmination of a signalling pathway that requires prior expression of the tumour suppressor protein P53 which trans-activates the gadd45 gene. P53 expression is in turn driven by the activity of the ATM gene product. GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38.
PMID:11274345

GADD45*@Cytoplasm

References
su_mpk1_mpk1_re217:( Survival  map ) Translation
su_mpk1_mpk1_re143( Survival  map ):
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1.
GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38
PMID:21614932 PMID:11274345

Modifications:
In compartment: Cytoplasm
  1. GADD45*@Cytoplasm map
Participates in complexes:
In compartment: Cytoplasm
  1. GADD45*:​MAP3K4|​pho@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. GADD45*@Cytoplasm map + MAP3K4@Cytoplasm map → map GADD45*:​MAP3K4|​pho@Cytoplasm map
  2. gGADD45*@Nucleus map → map GADD45*@Cytoplasm map
As Catalyser:
  1. MAP2K4@Cytoplasm map → map MAP2K4|​pho|​pho@Cytoplasm map
  2. MAP2K3@Cytoplasm map → map MAP2K3|​pho|​pho@Cytoplasm map
  3. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map