SUR-8*

Protein SUR-8*

Identifiers
soc-2 suppressor of clear homolog (C. elegans)
"soc-2 (suppressor of clear C.elegans) homolog"
HUGO:SHOC2 HGNC:15454 ENTREZ:8036 UNIPROT:Q9UQ13

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK

References
Sur-8 contributes to the Raf activation process by promoting the dephosphorylation of the inhibitory N-terminal 14-3-3 binding site on Raf.
PMID:17496910

SUR-8*@Cytoplasm

References
su_mpk1_mpk1_re13( Survival ):
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high a???nity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910
su_mpk1_mpk1_re21( Survival ):
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway.
PMID:19289794 PMID:17496910
su_mpk1_mpk1_re55( Survival ):
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf and thus its recruitment.
PMID:17496910
su_mpk1_mpk1_re62( Survival ):
The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles.
The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation.
PMID:11226259 PMID:19565474

Modifications:
In compartment: Cytoplasm

SUR-8*@Cytoplasm

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser: