Protein MMP14* map

Identifiers
HUGO:MMP14
matrix metallopeptidase 14 (membrane-inserted)
HUGO:MMP14, HGNC:7160, ENTREZ:4323, UNIPROT:P50281, GENECARDS:GC14P023305??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

MMP14*@Extracellular space

References
em_emtc_emtc_re350( EMT Senescence  map ):
PMID:21900405
LAP contains an integrin-binding site called RBD
Several RBD-binding integrins are able to activate latnet TGFB complex through binding this site.
PMID:21909923
The previously mentionned integrins are: a8b1, aVb1, aVb5, aVb6, aVb8.
In the complex Ingergin-large latent TGFB complex, I picked aVb6 as example. But a8b1, aVb1, aVb5, and aVb8 can active TGFB with the same mechanism.
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction, without participation of MMPs, so no hydrolyse or clevage
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP
em_emtc_emtc_re1586( EMT Senescence  map ):
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.

Modifications:
In compartment: Extracellular space
  1. MMP14*@Extracellular space map
In compartment: default
  1. MMP14*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP14@Extracellular space map → map MMP14*@Extracellular space map
    2. MMP14@Cytosol map → map MMP14*@default map
    3. MMP14*@default map → map Invasion@default map
    As Catalyser:
    1. MMP2@Extracellular space map → map MMP2*@Extracellular space map
    2. Laminin5*@Extracellular space map → map Truncated Laminin5*@Extracellular space map
    3. Fibronectin*@Extracellular space map → map Truncated Fibronectin*@Extracellular space map
    4. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map