Identifiers
HUGO:CD247

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / SMAC 
 Innate Immunity   / FC_RECEPTORS 

References
PMID:9738502 PMID:21059766 PMID:11353765
 NATURAL_KILLER 
 MACROPHAGE 
CASCADE:NKP46
CASCADE:NKP30
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
PMID:10562324, PMID:23414611
To initiate signal transduction, NKp30 associates with immunoreceptor tyrosine based activation motif (ITAM)-containing adaptor proteins, such as disulfide-linked homodimers of CD247 (CD3zeta).
PMID:23414611, PMID:23414611, PMID:9625766
Nkp46 (NCR1) is the most specific marker of NK cells reported so far. For signalling, NKp46 associates with CD247 (CD3??) and also with the ??-chain of Fc??RI. Nkp46 signaling is activated by unknown ligands expressed on tumor cells.
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

1. CD247@INNATE_IMMUNE_CELL_Cytosol

1. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane
2. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane
3. CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane
4. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
5. CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
6. CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
7. CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane

1. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC
2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC
3. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
4. CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC
5. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC

1. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC → CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC + PTPRC@dSMAC
2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC → CD247:​CD3*:​alpha_/beta_TCR*@cSMAC
3. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC
4. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC + ZAP70@cSMAC → CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
5. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
6. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → degraded
7. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane → CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane
8. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane → CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
9. CD247@INNATE_IMMUNE_CELL_Cytosol + Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane → CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane
10. CD247@INNATE_IMMUNE_CELL_Cytosol + NKp30*@INNATE_IMMUNE_CELL_Membrane → CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane
11. FCER1G@INNATE_IMMUNE_CELL_Membrane + NKp46*@INNATE_IMMUNE_CELL_Membrane + CD247@INNATE_IMMUNE_CELL_Cytosol → CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
12. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR + FCER1G@INNATE_IMMUNE_CELL_Membrane → CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane

1. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell + PXN|​pho@T_cell → PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell
2. p38*@T_cell → p38*|​Tyr323_pho@T_cell
3. CD6@cSMAC → CD6|​pho@cSMAC
4. LAT@T_cell + PLCG1@T_cell + GRB2@T_cell + GRAP2@T_cell + GRAP@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell
5. GAB2@T_cell → GAB2|​pho@T_cell
6. LCP2@T_cell → LCP2|​pho@T_cell
7. VAV2@T_cell → VAV2|​pho@T_cell
8. VAV3@T_cell → VAV3|​pho@T_cell
9. gCK2@T_cell → rCK2*@T_cell
10. gTBX21@INNATE_IMMUNE_CELL_Cytosol → rTBX21@INNATE_IMMUNE_CELL_Cytosol
11. SYK@INNATE_IMMUNE_CELL_Cytosol → SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
12. ZAP70@INNATE_IMMUNE_CELL_Cytosol → ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
13. SHC1@INNATE_IMMUNE_CELL_Cytosol → SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol
14. IL2@INNATE_IMMUNE_CELL_Cytosol → IL2@default