Protein CDH1 map

Identifiers
HUGO:CDH1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map

References
PMID:16424155
CASCADE:KLRG1
 NATURAL_KILLER  map
PMID:16461340, PMID:16424155, PMID:17617594
Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on subsets of natural killer (NK) cells.
Putative KLRG1 ligands are expressed ubiquitously in melanoma and carcinoma cell lines.1 binds three of the classical cadherins (E (CDH1), N (CDH2), and R(CDH4)).
E-cadherin binding of KLRG1 prevents the lysis of E-cadherin???expressing targets by KLRG1+ NK cells.
Tumor-associated E-cadherin mutations interfere with KLRG1 interaction, human KLRG1 failed to bind to ??8 and ??9 E-cadherin mutants.

Modifications:
In compartment: Cancer_cell
  1. CDH1@Cancer_cell map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. CDH1@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CDH1:​CDH2:​CDH4:​KLRG1*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. Ligands_of_Inhibiting_immune checkpoints@Cancer_cell map → map CDH1@Cancer_cell map
  2. CDH1@TUMOR_CELL_AS_INDUCTOR_Membrane map + KLRG1*@INNATE_IMMUNE_CELL_Membrane map + CDH2@TUMOR_CELL_AS_INDUCTOR_Membrane map + CDH4@TUMOR_CELL_AS_INDUCTOR_Membrane map → map CDH1:​CDH2:​CDH4:​KLRG1*|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. KLRG1@T_cell map + PTPN11@T_cell map + SHIP1*@T_cell map → map KLRG1:​PTPN11:​SHIP1*@T_cell map
  2. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  3. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map