Protein IGF2 map

Identifiers
HGNC:5466
insulin like growth factor 2
HUGO:IGF2 hgnc_id:HGNC:5466 HGNC:5466 ENTREZ:3481 UNIPROT:P01344
insulin-like growth factor 2 (somatomedin A)
HUGO:IGF2 HGNC:5466 ENTREZ:3481 UNIPROT:P01344
HUGO:IGF2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:17145802
CASCADE:INTEGRIN
PMID:17600088
IIntegrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.
PMID:24668028
IGF2 expressed by CAFs promotes tumor growth
PMID:11237532
In breast cancers, both IGF-I and IGF-II
are expressed in the stromal ???broblasts and expression
of IGF-II in particular correlates with tumor progression
PMID:15003992
TGF-?? induced the myofibroblast phenotype via a CTGF-dependent pathway,
CTGF mediates EGF-stimulated proliferation and IGF-2-induced differentiation of fibroblasts
PMID:24668028 PMID:11237532

Modifications:
In compartment: Cytosol
  1. IGF2@Cytosol map
In compartment: Extracellular Matrix
  1. IGF2@Extracellular Matrix map
In compartment: Extracellular space
  1. IGF2@Extracellular space map
In compartment: Membrane
  1. IGF2@Membrane map
In compartment: default
  1. IGF2@default map
Participates in complexes:
In compartment: Cytosol
  1. IGF2:​IGF2R@Cytosol map
In compartment: Membrane
  1. IGF2:​IGF2R@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IGF2@Extracellular Matrix map → map IGF1/2*@Extracellular Matrix map
  2. IGF2@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  3. rIGF2@Cytosol map → map IGF2@Cytosol map
  4. IGF2@Cytosol map → map IGF2@default map
  5. IGF2@default map + IGF2R@Cytosol map → map IGF2:​IGF2R@Cytosol map
  6. IGF2:​IGF2R@Cytosol map → map degraded
  7. IGF family*@Extracellular space map → map IGF2@Extracellular space map
  8. IGF2@Membrane map + IGF2R@Membrane map → map IGF2:​IGF2R@Membrane map
  9. IGF2:​IGF2R@Membrane map → map degraded
As Catalyser:
  1. IGF1R@Cytosol map → map IGF1R|​pho@Cytosol map
  2. IGF1R@Membrane map → map IGF1R|​pho@Membrane map