Protein IGF2R map

Identifiers
HUGO:IGF2R

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
PMID:27548915
One function of IGF2R is to bind to the ligand IGF2, leading to IGF2 degradation and consequently an inhibition of the growth stimulation that results from the interaction between IGF2 and IGF1R48, 49. IGF2 is upregulated in CAFs50, suggesting that IGF2R is inhibited. Therefore, reduction in IGF2R following treatment with miR-211 or melanosomes may increase IGF2 levels, promoting its binding to IGF1R, and thus leading to hyperactivation of this pathway and increased proliferation.

Modifications:
In compartment: Cytosol
  1. IGF2R@Cytosol map
In compartment: Membrane
  1. IGF2R@Membrane map
Participates in complexes:
In compartment: Cytosol
  1. IGF2:​IGF2R@Cytosol map
In compartment: Membrane
  1. IGF2:​IGF2R@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IGF2@default map + IGF2R@Cytosol map → map IGF2:​IGF2R@Cytosol map
  2. IGF2:​IGF2R@Cytosol map → map degraded
  3. rIGF2R@Cytosol map → map IGF2R@Cytosol map
  4. IGF2@Membrane map + IGF2R@Membrane map → map IGF2:​IGF2R@Membrane map
  5. IGF2:​IGF2R@Membrane map → map degraded
As Catalyser: