Protein SERPINE1 map

Identifiers
serpin family E member 1
HUGO:SERPINE1 hgnc_id:HGNC:8583 HGNC:8583 ENTREZ:5054 UNIPROT:P05121

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
_INHIBITION_ANTITUMOR
PMID:11021826
Fibroblastic expression (immunohistocheemistry) of both uPA and uPAR were positively correlated with tumor size.
fibroblastic expression of PAI1 was related to the presence of invasion
PMID:25502501
SERPINE1, which encodes PAI-1 and is a target of YAP/TAZ
PAI-1 has been definitively linked to both profibrotic functions of cultured fibroblasts (20) and fibrosis in animal models and human disease.
PMID:20027185
The proteolytic activities of uPA and plasmin are antagonized by the serine protease inhibitors (serpins) plasminogen activator inhibitor 1 (PAI1; also known as SERPINE1) and PAI2 (also known as SERPINB2)

Modifications:
In compartment: Cytosol
  1. SERPINE1@Cytosol map
In compartment: default
  1. SERPINE1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSERPINE1@Cytosol map → map SERPINE1@Cytosol map
    2. SERPINE1@default map → map Fibrosis@default map
    3. SERPINE1@Cytosol map → map SERPINE1@default map
    As Catalyser:
    1. proPLAU*@default map → map PLAU@default map
    2. PLG@default map → map Plasmin@default map