Protein proPLAU* map

Identifiers
plasminogen activator, urokinase
HUGO:PLAU hgnc_id:HGNC:9052 HGNC:9052 ENTREZ:5328 UNIPROT:P00749

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
CASCADE:FGF
CASCADE:EGF
PMID:11021826
Fibroblastic expression (immunohistocheemistry) of both uPA and uPAR were positively correlated with tumor size.
fibroblastic expression of PAI1 was related to the presence of invasion
PMID:19631971
co-culturing fibroblasts with ovarian cancer cells (ES-2) led to induction of uPA in fibroblasts; the same effect was observed when the fibroblasts were grown in ES-2 cell-conditioned medium. The basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) were the cancer cell-derived paracrine factors inducing uPA transcription in the fibroblasts.

Modifications:
In compartment: Cytosol
  1. proPLAU*@Cytosol map
In compartment: default
  1. proPLAU*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. proPLAU*@default map → map PLAU@default map
    2. proPLAU*@Cytosol map → map proPLAU*@default map
    3. rPLAU@Cytosol map → map proPLAU*@Cytosol map
    As Catalyser: