Protein SIRT3 map

Identifiers
sirtuin 3
HUGO:SIRT3 hgnc_id:HGNC:14931 HGNC:14931 ENTREZ:23410 UNIPROT:Q9NTG7
HUGO:SIRT3 HGNC:14931 ENTREZ:23410 UNIPROT:Q9NTG7

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
_INHIBITION_ANTITUMOR
PMID:22850421,PMID:21358671
SIRT3 is involved in the control of HIF1 expression, and redox signaling.
A decrease in SIRT3 expression leads to increased superoxide dismutase 2 (SOD2) acetylation/inhibition, thereby causing ROS increase and HIF1 stabilization.
SIRT3 is upregulated in normal fibroblasts and downregulated in CAFs.
PMID:21109197
SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production (in vitro data)

SIRT3@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re1074( Regulated Cell Death  map ):
PMID:16788062
PMID:16790548
in mouse cells

Modifications:
In compartment: Cytosol
  1. SIRT3@Cytosol map
In compartment: Mitochondrial Matrix
  1. SIRT3@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SIRT3@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
    2. SIRT3@Cytosol map → map ROS production@Cytosol map
    As Catalyser:
    1. SOD2|​ace@Cytosol map → map SOD2@Cytosol map
    2. HMGCS2|​ace@Cytosol map → map HMGCS2@Cytosol map
    3. rHIF1A@Cytosol map → map HIF1A@Cytosol map
    4. ACSS1|​K642_ace@Mitochondrial Matrix map + NAD_super_+_endsuper_@Mitochondrial Matrix map → map ACSS1@Mitochondrial Matrix map + NADH@Mitochondrial Matrix map