Protein HMGCS2 map

Identifiers
HUGO:HMGCS2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:27833036
CAFs secrete large amounts of ketone bodies which are then re-utilized by tumor cells for anabolic metabolism or OXPHOS like lactat
PMID:23082722
Coculture with fibroblasts overexpressing BDH1 or HMGCS2 increases the cancer cell
population. Probably via keton bodies production.
PMID:21109197
SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production (in vitro data)

Modifications:
In compartment: Cytosol
  1. HMGCS2@Cytosol map
  2. HMGCS2|​ace@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HMGCS2@Cytosol map → map Keton_body_production@default map
    2. HMGCS2|​ace@Cytosol map → map HMGCS2@Cytosol map
    As Catalyser: