Complex SMAD2:SMAD4 map
Complex composition:

  1. SMAD2 map
  2. SMAD4 map

SMAD2|​pho:​SMAD4@Cytosol

Identifiers
NAME:SMAD2:SMAD4

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:TGFB
PMID:23784029
TGFB upregulates FSP1 (S100A4) expression via Smad2 and smad3
Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation.

SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:SMAD2:SMAD4

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
CASCADE:TGFB
 MACROPHAGE  map
 NATURAL_KILLER  map
in_re471( Innate Immunity  map ):
PMID:12193690
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
PMID:10925299, PMID:6357187
IL-13 induces de novo synthesis of arginase I mRNA and protein. Probably via STAT6.
PMID:23390297
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD23.
in_re485( Innate Immunity  map ):
PMID:11875494
HMOX1 (HO1) mediates the inhibitory effect of IL10
on LPS-induced NOS2 (INOS) expression.
PMID:6357187, PMID:8871614
IL13 downregulates INOS activity via ILRA1/STAT6 pathway.
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and
transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10.
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression.
PMID:17689680
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
MIF inhitits expression of M1 markers such as NOS2 (INOS).
PMID;PMID:20194441
HIF1 upregulates expression of INOS.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. SMAD2|​pho:​SMAD4@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SMAD2|​pho@Cytosol map + SMAD4@Cytosol map → map SMAD2|​pho:​SMAD4@Cytosol map
  2. SMAD2|​pho@INNATE_IMMUNE_CELL_Cytosol map + SMAD4@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2|​pho:​SMAD4@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gS100A4@Cytosol map → map rS100A4@Cytosol map
  2. gITGA11@Cytosol map → map rITGA11@Cytosol map
  3. gPOSTN@Cytosol map → map rPOSTN@Cytosol map
  4. gNOX4@Cytosol map → map rNOX4@Cytosol map
  5. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
  6. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  7. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
  8. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
  9. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  10. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map