Protein KLF4 map

Identifiers
HUGO:KLF4

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS

References
PMID: PMID:21670502
KLF4 together with STAT6 upregulates expression of PPARG and ARG1 downstream of IL4.
KLF4-deficient macrophages demonstrated increased proinflammatory gene expression, enhanced bactericidal activity, and altered metabolism.
KLF4 inhibits PTGS2 (COX2) expression. Probably via prevention of NFkB activaiton.

KLF4@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. KLF4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rKLF4@Cytosol map → map KLF4@Cytosol map
    As Catalyser:
    1. gARG1@Cytosol map → map rARG1@Cytosol map
    2. gPPARG@Cytosol map → map rPPARG@Cytosol map
    3. gMRC1@Cytosol map → map rMRC1@Cytosol map
    4. gPTGS2@Cytosol map → map rPTGS2@Cytosol map