Protein CXCR4 map

Identifiers
HUGO:CXCR4

Maps_Modules
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
MODULE:MACROPHAGE

References
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:22025564
PGE(2) was essential both for expression of functional CXCR4 in cancer-associated MDSCs and for production of its ligand CXCL12. Frequencies of CD11b(+)CD14(+)CD33(+)CXCR4(+) MDSCs closely correlated with CXCL12 and PGE(2) levels in patient ascites. MDSCs migrated toward ovarian cancer ascites in a CXCR4-dependent manner that required COX2 activity and autocrine PGE(2) production.

CXCR4@Membrane

Identifiers

Maps_Modules

References

Modifications:
In compartment: Membrane
  1. CXCR4@Membrane map
Participates in complexes:
In compartment: Membrane
  1. CXCL12:​CXCR4@Membrane map
Participates in reactions:
As Reactant or Product:
  1. rCXCR4@Cytosol map → map CXCR4@Membrane map
  2. CXCL12:​CXCR4@Membrane map → map Migration into tumor@default map
  3. CXCL12@default map + CXCR4@Membrane map → map CXCL12:​CXCR4@Membrane map
As Catalyser: