Protein CXCL12 map

Identifiers
HUGO:CXCL12

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
PMID:20644254
CXCR4, the receptor for the chemokine CXCL12 (also known as SDF-1), also plays an important role in facilitating macrophage migration in vivo.
PMID:22025564
PGE(2) was essential both for expression of functional CXCR4 in cancer-associated MDSCs and for production of its ligand CXCL12 by tumor cells. Frequencies of CD11b(+)CD14(+)CD33(+)CXCR4(+) MDSCs closely correlated with CXCL12 and PGE(2) levels in patient ascites. MDSCs migrated toward ovarian cancer ascites in a CXCR4-dependent manner that required COX2 activity and autocrine PGE(2) production.

CXCL12@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: default
  1. CXCL12@default map
Participates in complexes:
In compartment: Membrane
  1. CXCL12:​CXCR4@Membrane map
Participates in reactions:
As Reactant or Product:
  1. CXCL12:​CXCR4@Membrane map → map Migration into tumor@default map
  2. CXCL12@default map + CXCR4@Membrane map → map CXCL12:​CXCR4@Membrane map
As Catalyser: