Protein HMGB1 map

Identifiers
HUGO:HMGB1
high mobility group box 1
HUGO:HMGB1 hgnc_id:HGNC:4983 HGNC:4983 ENTREZ:3146 UNIPROT:P09429

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
 Regulated Cell Death  map  / PYROPTOSIS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
PMID:27192565 PMID:22842346
PMID:19931333
PMID:26618107
PMID:27048821
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IL18
CASCADE:TLR2_4
CASCADE:IFNG
CASCADE:TNF
PMID:15802534
Activated NK cells release HMGB1, which promotes inflammation and induces DC maturation.
IL-18 induces HMGB1 secretion by NK cells
PMID:12646658
IFNG upregulates protein level and secretion of HMGB1 partially via TNF induction in macrophages

Modifications:
In compartment: Cancer_cell
  1. HMGB1@Cancer_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Ligands_of_Inhibiting_immune checkpoints@Cancer_cell map → map HMGB1@Cancer_cell map
    As Catalyser:
    1. BAG6:​HAVCR2@T_cell map + FYN@T_cell map → map FYN:​HAVCR2|​pho@T_cell map + BAG6@T_cell map