Protein FYN map

Identifiers
HUGO:FYN
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:21378271
PMID:19290918 PMID:9738502 PMID:12218089 PMID:10648627 PMID:27192565 PMID:22863785
 NATURAL_KILLER  map
CASCADE:NKP44
CASCADE:NKP30
CASCADE:NKP46
CASCADE:SLAMF7
CASCADE:LFA1
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:12731048, PMID:20814939
Upon engagement of activating receptors, the tyrosine-containing adapters undergo tyrosine phosphorylation mediated by Src family kinases (SFKs)??.
Cross-linking of Nkp30 or Nkp46 or NKp44 resulted in strong tyrosine phosphorylation of LCK anf FYN kinases.
PMID:10591186, PMID:24440149
Cross-Linking of LFA-1 induces tyrosine Phosphorylation of DNAM-,FYN probably phosphorylates DNAM1 Y322 in NK cells
PMID:22683124
Fyn-deficient NK cells exhibited defective killing.
PMID:19909365
FYN is adaptor protein f Fc epsilon RI signaling in mast cells

Modifications:
In compartment: T_cell
  1. FYN@T_cell map
In compartment: cSMAC
  1. FYN|​Y528_pho@cSMAC map
  2. FYN|​Y417_pho|​active@cSMAC map
Participates in complexes:
In compartment: T_cell
  1. FYN:​HAVCR2|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. BAG6:​HAVCR2@T_cell map + FYN@T_cell map → map FYN:​HAVCR2|​pho@T_cell map + BAG6@T_cell map
  2. FYN|​Y528_pho@cSMAC map → map FYN@T_cell map
  3. FYN@T_cell map → map FYN|​Y528_pho@cSMAC map
  4. FYN@T_cell map → map FYN|​Y417_pho|​active@cSMAC map
  5. FYN:​HAVCR2|​pho@T_cell map → map Regulation_of_T-cell_apoptosis@T_cell map
  6. FYN:​HAVCR2|​pho@T_cell map → map T-cell_anergy@T_cell map
As Catalyser:
  1. CD28@T_cell map → map CD28|​pho|​active@cSMAC map
  2. CD226@T_cell map → map CD226|​pho|​active@T_cell map
  3. WASP*@T_cell map → map WASP*|​Tyr291_pho|​active@T_cell map
  4. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + PTPRC@dSMAC map
  5. PAG1@T_cell map → map PAG1|​pho@T_cell map
  6. rIFNG@T_cell map → map IFNG@T_cell map
  7. FYN@T_cell map → map FYN|​Y417_pho|​active@cSMAC map
  8. TRAT1@cSMAC map → map TRAT1|​pho@cSMAC map