Protein CSK map

Identifiers
HUGO:CSK

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map

References
PMID:19290918 PMID:10790433 PMID:12485116 PMID:11181701
CASCADE:2B4
 NATURAL_KILLER  map
PMID:15713798
The phosphorylated third ITSM of 2B4 can recruit the phosphatases SHP-1, SHP-2, SHIP, and the inhibitory kinase Csk. SAP acts as an inhibitor of interactions between 2B4 and these negative regulatory molecules, explaining how 2B4 inhibits NK-cell activation in the absence of functional SAP.
PMID:8011291, PMID:8986721
CSK probably inhibit LCK in NK (demonstrated in T-cells only)

Modifications:
In compartment: T_cell
  1. CSK@T_cell map
  2. CSK|​S364_pho|​active@T_cell map
Participates in complexes:
In compartment: T_cell
  1. CSK:​PAG1|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. CSK@T_cell map → map CSK|​S364_pho|​active@T_cell map
  2. CSK@T_cell map + PAG1|​pho@T_cell map → map CSK:​PAG1|​pho@T_cell map
  3. CSK:​PAG1|​pho@T_cell map → map PAG1@T_cell map + CSK@T_cell map
As Catalyser:
  1. FYN@T_cell map → map FYN|​Y528_pho@cSMAC map
  2. LCK@cSMAC map → map LCK|​Y505_pho@cSMAC map