Identifiers
HUGO:PTEN
phosphatase and tensin homolog
HUGO:PTEN hgnc_id:HGNC:9588 HGNC:9588 ENTREZ:5728 UNIPROT:P60484
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
HUGO:PTEN, HGNC:9588, ENTREZ:5728, UNIPROT:P60484, GENECARDS:GC10P089613
HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484
HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN
phosphatase and tensin homologue
BZS, MHAM
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CAF_INHIBITION_ANTITUMOR
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
EMT Senescence / SENESCENCE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
PMID:16982858 PMID:23732914
PMID:24254977
PMID:19847259
Fibroblast-speci???c deletion
of Pten in this manner resulted in increased primary tumour growth
the authors linked Pten loss
in ???broblasts to increased Ras???Akt signalling, as well
as increased activity of the Ets-2 transcription factor
and associated increases in expression of MMP9, an
Ets-2 target genes.
PMID:10753747
Pten regulates PI3K pathway via its phosphatase activity on phosphatidylinositol (PI) 3,4,5-trisphosphate (PI(3,4,5)P3), a product of PI 3-kinase.
Pten-deficient fibroblasts migrate faster than wild type.
there are marked increases of the GTP-bound forms of Rac1 and Cdc42 in logarithmically growing Pten???/??? cells compared to wild-type cells, although the total protein levels are not affected by the Pten status.
similar to Akt, Rac1 and Cdc42 activation in Pten???/??? cells is downstream of PI 3-kinase.
PMID:11747822
phosphorylation of Akt is elevated in the PTEN-deficient mouse embryonic fibroblasts (PTEN???/??? MEFs) compared to the level in PTEN+/??? MEFs (Figure 4b) and that the cell motility of the PTEN-deficient MEFs is higher than that of PTEN+/??? MEFs
PMID:25364523
We cultured cardiac fibroblasts of mice were in hypoxia or normoxia conditions for 12, 24 and 48 hours. At all the time points, caveolin-1 and PTEN expression were gradually reduced, whereas, ??-SMA was gradually increased.
PMID:22179046
MiR-320 is a Pten target in fibroblasts that suppresses tumor growth
Ets2 is a direct target of miR-320 in fibroblasts
Mmp9 and Emilin2 are directly regulated by miR-320 via their 3??? UTR target sequences
PMID:15721744
PMID:22465479
PMID:12040186
PMID:16288286
PMID:17218262