Phenotype Stress fiber formation map
Stress fiber formation@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
em_emtc_emtc_re695( EMT Senescence  map ):
PMID:11724822
Insulin-like growth factor (IGF)-1 plays crucial roles in growth control and rearrangements of the cytoskeleton
LARG is an Rho guanine nucleotide exchange factor, which contains a PDZ domain responsible for IGF-1 binding.
LARG induced the formation of stress fibers in NIH 3T3 fibroblasts.
MDCKII epithelial cells treated with IGF-1 results in activated Rho and its effector Rho-associated kinase and actin stress fibers were enhanced.
IGF-1 activates the Rho pathway via a LARG/IGF-1 receptor complex and thereby regulates cytoskeletal rearrangements.
em_emtc_emtc_re716( EMT Senescence  map ):
PMID:9265657
ERM proteins can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac

Modifications:
In compartment: Cytosol
  1. Stress fiber formation@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. em_emtc_emtc_s2905 → map Stress fiber formation@Cytosol map
    2. ERM*|​open@Cytosol map → map Stress fiber formation@Cytosol map
    As Catalyser: