References
PMID:11724822
Insulin-like growth factor (IGF)-1 plays crucial roles in growth control and rearrangements of the cytoskeleton
LARG is an Rho guanine nucleotide exchange factor, which contains a PDZ domain responsible for IGF-1 binding.
LARG induced the formation of stress fibers in NIH 3T3 fibroblasts.
MDCKII epithelial cells treated with IGF-1 results in activated Rho and its effector Rho-associated kinase and actin stress fibers were enhanced.
IGF-1 activates the Rho pathway via a LARG/IGF-1 receptor complex and thereby regulates cytoskeletal rearrangements.