Complex ATF3:SMAD2_3*:SMAD4 map
Complex composition:

  1. SMAD2_3* map
  2. SMAD4 map
  3. ATF3 map

ATF3:​SMAD2_3*:​SMAD4@Nucleus

Identifiers
NAME:ATF3:SMAD2_3*:SMAD4

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
em_emtc_emtc_re1225( EMT Senescence  map ):
PMID:17490644
Snai1 and TCF3 (E47) upregulate both mRNA and protein level of ID1
This upregulation depends on SP1 or AP1 co-transcription factors
Erk contributes to the recruitment or assembly of proteins to Id-1 promoter
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. ATF3:​SMAD2_3*:​SMAD4@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. SMAD2_3*:​SMAD4@Nucleus map + ATF3@Nucleus map → map ATF3:​SMAD2_3*:​SMAD4@Nucleus map
As Catalyser:
  1. gID1@Nucleus map → map rID1@Nucleus map