Protein LAP map

Identifiers
TGFB induced factor homeobox 1
HUGO:TGIF1 hgnc_id:HGNC:11776 HGNC:11776 ENTREZ:7050 UNIPROT:Q15583

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 Cancer Associated Fibroblasts  map  / TREG_MODULATORS  map

References
CASCADE:TGFB
PMID:26519775
The ??v-containing integrins ??v??1, ??v??3, ??v??5, and ??v??8 in a variety of fibroblasts and pericytes are reported to activate latent TGF-?? by binding to the RGD motif of the latency-associated protein (LAP) that is bound to TGF-?? and the latent TGF-?? binding protein (LTBP) forming the large latent complex (LLC)

Modifications:
In compartment: Cytosol
  1. LAP@Cytosol map
In compartment: default
  1. LAP@default map
Participates in complexes:
In compartment: Cytosol
  1. LAP:​LTBP*:​TGFB*@Cytosol map
In compartment: Treg modulation
  1. LAP:​LTBP*:​TGFB*@Treg modulation map
In compartment: default
  1. LAP:​LTBP*:​TGFB*@default map
Participates in reactions:
As Reactant or Product:
  1. LAP:​LTBP*:​TGFB*@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  2. LAP:​LTBP*:​TGFB*@default map → map TGFB*@default map + LAP@default map + LTBP*@default map
  3. TGFB*@Cytosol map + LTBP*@Cytosol map + LAP@Cytosol map → map LAP:​LTBP*:​TGFB*@Cytosol map
  4. LAP:​LTBP*:​TGFB*@Cytosol map → map LAP:​LTBP*:​TGFB*@default map
  5. LAP:​LTBP*:​TGFB*@Cytosol map → map LAP:​LTBP*:​TGFB*@Treg modulation map
As Catalyser: