Gene PDGFR* map

Identifiers
HUGO:PDGFRA HUGO:PDGFRB

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:PDGF
CASCADE:LIF
CASCADE:TGFB
PMID:19118022
Fibroblasts expressed high amounts of osteopontin, and stimulation with PDGF-CC for 6 h increased the production even further, by 2.4-fold compared to unstimulated fibroblasts, demonstrating that the expression of osteopontin is directly regulated by signaling induced by PDGF-CC in fibroblasts
probably via PDGFR-??.
PMID:24857661
we noted an increased expression of PDGFR?? after LIF stimulation in hPDF
PMID:26921338
TGFB induces expression of PDGFB and PDGFR in CAFs and indirectly suppresses PEDF expression via PDGFB signaling

Modifications:
In compartment: Cytosol
  1. gPDGFR*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gPDGFR*@Cytosol map → map rPDGFR*@Cytosol map
    As Catalyser: