Protein JUND map

Identifiers
HUGO:JUND
jun D proto-oncogene
HUGO:JUND HGNC:6206 ENTREZ:3727 UNIPROT:P17535 GENECARDS:JUND KEGG:3727 ATLASONC:JUNDID179 WIKI:JUND

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:20535745
junD???/??? fibroblasts exhibit features of carcinoma-associated myofibroblasts.
The expression of the chemokine CXCL12 was increased in junD???/??? fibroblasts
HIF-1?? protein accumulates in junD???/??? fibroblasts and mice (Gerald et al, 2004; Laurent et al, 2008), the up-regulation of CXCL12 in junD???/??? fibroblasts could be mediated, at least partly, through HIF. Specific inhibition of HIF-1?? by siRNA strongly reduced HIF-1?? mRNA levels (Fig S3A) and decreased the expression of its target gene, CXCL12

Modifications:
In compartment: Cytosol
  1. JUND@Cytosol map
In compartment: Nucleus
  1. JUND@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. JUND@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
    2. JNK pathway@Cytoplasm map → map JUND@Nucleus map
    3. JUND@Nucleus map → map Transcription@Nucleus map
    As Catalyser:
    1. gCXCL12@Cytosol map → map rCXCL12@Cytosol map
    2. gHIF1A@Cytosol map → map rHIF1A@Cytosol map