Complex CyclinY*:PFTK*
Complex composition:
- CyclinY*
- PFTK*
CyclinY*:PFTK*@Cytoplasm
Identifiers
NAME:CyclinY*:PFTK*
References
s_wca1_re36( Survival
):
PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573
ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A
ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand
WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- CyclinY*:PFTK*@Cytoplasm
Participates in reactions:
As Reactant or Product:
As Catalyser:- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→
AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome