Protein PKM2* map

Identifiers
HUGO:PKM
pyruvate kinase, muscle
HUGO:PKM HGNC:9021 ENTREZ:5315 UNIPROT:P14618

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 Regulated Cell Death  map  / RCD_GENES  map

References
PMID:22101652; PMID:19923890
The M1 or M2 splice isoforms of pyruvate kinase (PK), a mandatory regulatory glycolytic enzyme, shift glucose metabolism towards aerobic glycolysis (PKM2) or oxidative phosphorylation (PKM1)
PKM2 and lactate dehydrogenase are highly expressed in the stroma of breast cancer lacking caveolin-1 expression

Modifications:
In compartment: Cytosol
  1. PKM2*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. PKM2*:​fructose-1,6P2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rPKM2@Nucleus map → map PKM2*@Cytosol map
  2. PKM2*@Cytosol map → map Oxidative Phosphorylation@Mitochondrial inner membrane map
  3. PKM2*:​fructose-1,6P2@Cytosol map → map K_super_+_endsuper_:​Mg2+:​PK*|​hm4@Cytosol map
  4. PKM2*@Cytosol map + fructose-1,6P2@Cytosol map → map PKM2*:​fructose-1,6P2@Cytosol map
As Catalyser:
  1. Phosphoenolpyruvate@Cytosol map → map piruvat@Cytosol map
  2. HIF1A@Cytosol map → map HIF1A@Nucleus map