Protein FN* map

Identifiers
fibronectin 1
HUGO:FN1 hgnc_id:HGNC:3778 HGNC:3778 ENTREZ:2335 UNIPROT:P02751

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map

References
CASCADE:HH
CASCADE:INTEGRIN
PMID:21674557
Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts.
This effect is mediated by up-regulation of specific genes related to a myo/contractile phenotype (ACTA2, CNN1,FN (ED-A containing), EDN1, MYL12A, TAGLN2) and inhibition of ACTG2 expression.
PMID:18353785
TGF??1-induced??v??3 expression is dependent on integrin-mediated cell adhesion; FN strongly potentiated the effect of TGF??1.
PMID:26519775
fibronectin is a ligand fo a5b1, avb3, avb5 integrins in CAFs

Modifications:
In compartment: Cytosol
  1. FN*@Cytosol map
In compartment: default
  1. FN*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FN*@Cytosol map → map ECM_REGULATION@default map
    2. FN*@Cytosol map → map FN*@default map
    3. FN*@Cytosol map → map FN*@default map
    4. rFN*@Cytosol map → map FN*@Cytosol map
    As Catalyser:
    1. ca_s4773 → map ca_s4773
    2. ca_s4776 → map ca_s4776
    3. ca_s4687 → map ca_s4687
    4. ca_s4779 → map ca_s4779