RNA LOX map

Identifiers
HUGO:LOX

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map

References
CASCADE:TGFB
PMID:21498085
TGF-??1 treatment significantly upregulated LOX mRNA and protein expression in cardiac fibroblasts, as well as activity in the cell-conditioned media.
The increase of LOX protein in response to TGF-??1 was prevented by inhibitors of PI3K, Smad3, p38-MAPK, JNK and ERK1/2. Blockade of PI3K also decreased TGF-??1 induced phosphorylation of Smad3, suggesting that the PI3K/Akt and Smad pathways may be integrated in TGF-??1 signaling.

Modifications:
In compartment: Cytosol
  1. rLOX@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gLOX@Cytosol map → map rLOX@Cytosol map
    2. rLOX@Cytosol map → map LOX@Cytosol map
    As Catalyser: