Protein LOX map

Identifiers
lysyl oxidase
HUGO:LOX hgnc_id:HGNC:6664 HGNC:6664 ENTREZ:4015 UNIPROT:P28300

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map

References
CASCADE:TGFB
PMID:19931152
Lysyl oxidase (LOX), a copper-dependent amine oxidase (Kagan and Li 2003) which initiates the process of covalent intra- and intermolecular crosslinking of collagen by oxidatively deaminating specific lysine and hydroxylysine residues located in the telopeptide domain.
CAFs are expressing LOX, inhibiting LOX activity reduces collagen crosslinking, tempers tissue fibrosis, decreases focal adhesions, and impedes tumor progression to reduce breast tumor incidence.

Modifications:
In compartment: Cytosol
  1. LOX@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LOX@Cytosol map → map ECM_REGULATION@default map
    2. rLOX@Cytosol map → map LOX@Cytosol map
    As Catalyser: