Protein TDG map

Identifiers
thymine-DNA glycosylase
HUGO:TDG, HGNC:11700, ENTREZ:6996, UNIPROT:Q13569

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / BER  map

References
PMID:17129768, PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013

TDG|​don@Nucleus

References
ce_re196( Cell Cycle DNA Repair  map ):
TDG SUMOlation causes dissociation of TDG from DNA to allow the next step of BER pathway by APE proteins.
PMID:16626738

TDG@Nucleus

References
ce_re77:( Cell Cycle DNA Repair  map ) PMID:17129768
ce_re196( Cell Cycle DNA Repair  map ):
TDG SUMOlation causes dissociation of TDG from DNA to allow the next step of BER pathway by APE proteins.
PMID:16626738
ce_re480( Cell Cycle DNA Repair  map ):
9-1-1 complex activates TDG glycosylase and activates BER:
PMID:17855402

Modifications:
In compartment: Nucleus
  1. TDG@Nucleus map
  2. TDG|​don@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. RAD23*:​TDG:​XPC@Nucleus map
  2. HUS1:​RAD1:​RAD9*|​pho:​TDG@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. TDG@Nucleus map → map TDG|​don@Nucleus map
  2. TDG|​don@Nucleus map → map degraded
  3. TDG@Nucleus map + HUS1:​RAD1:​RAD9*|​pho@Nucleus map → map HUS1:​RAD1:​RAD9*|​pho:​TDG@Nucleus map
  4. TDG@Nucleus map + XPC@Nucleus map + RAD23*@Nucleus map → map RAD23*:​TDG:​XPC@Nucleus map
As Catalyser:
  1. gDeaminated_alkylated_mismatched_base*@Nucleus map → map gBER_M-glyc_DNA_st2*@Nucleus map + Base@Nucleus map