Identifiers
kinase insert domain receptor (a type III receptor tyrosine kinase)
HUGO:KDR, HGNC:6307, ENTREZ:3791, GENECARDS:GC04M055944
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.
PMID:11166270
VEGFR2 is highly specific towards VEGFA.
PMID:11741095
PMID:13678960
However VEGFR2 also binds to processed forms of VEGF-C, D, E.
VEGFR2 is expressed in both vascular endothelial and lymphatic endothelial cells.
Its expression has also been demonstrated in several other cell types such as megakaryocytes and haematopoietic stemm cells.
References
em_emtc_emtc_re373( EMT Senescence ):
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.