Identifiers
kinase insert domain receptor (a type III receptor tyrosine kinase)
HUGO:KDR, HGNC:6307, ENTREZ:3791, GENECARDS:GC04M055944, UNIPROT:P35968

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / ECM 

References
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.
PMID:11166270
VEGFR2 is highly specific towards VEGFA.
PMID:11741095
PMID:13678960
However VEGFR2 also binds to processed forms of VEGF-C, D, E.
VEGFR2 is expressed in both vascular endothelial and lymphatic endothelial cells.
Its expression has also been demonstrated in several other cell types such as megakaryocytes and haematopoietic stemm cells.
PMID:15501236
PMID:14739162
Although Endothelial cells express both receptors VEGFR1 and VEGFR2, only VEGFR2 is able to mediate angiogenic effects of VEGFA

References
em_emtc_emtc_re417( EMT Senescence  ):
PMID:15501236
VEGFR2 and aVb3 were observed to co-associate after stimulation with either L1 (Ig6 domain) or VEGFA (isoform of 165 amino acids)
VEGFR2 was tyrosine phosphorylated after stimulation with L1 (via Ig6 domain), even in the absence of exogenous VEGFA ( (isoform of 165 amino acids), indicating close cooperation between VEGFR2 and aVb3

1. VEGFR2*@Cytosol
2. VEGFR2*@Cytosol

1. L1CAM:​VEGFR2*|​hm2@Cytosol

1. rVEGFR2*@Nucleus → VEGFR2*@Cytosol
2. VEGFR2*@Cytosol → VEGFR2*@Cytosol
3. VEGFR2*@Cytosol + VEGFA@Extracellular space → em_emtc_emtc_s1628
4. L1CAM@Cytosol + VEGFR2*@Cytosol → L1CAM:​VEGFR2*|​hm2@Cytosol