Identifiers
NAME:Caveolin1*:Occludin*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence
/ EMT_REGULATORS
EMT Senescence
/ CELL_CELL_ADHESIONS
EMT Senescence
/ TIGHT_JUNCTIONS
References
em_emtc_emtc_re518( EMT Senescence
):
PMID:22671595
Caveolin-1 is an endocytic scaffolding protein
It binds independently to claudin-2 and occludin (co-immunoprecipitation assays).
The finding that caveolin-1 interacts with claudin-2 and occludin, but notwith claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components.