Identifiers
transforming growth factor, beta 3
HUGO:TGFB3, HGNC:11769, ENTREZ:7043, GENECARDS:GC14M076424
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:11790723
Whereas TGFB1 and 2 are proscarring growth factors, TGFB3 is antiscarring
TGFB1, 2, and 3 are embryonically expressed in skin and up-regulated at adult wound sites
Overlapping expression patterns of HIF1Aand TGFB3 in vivo
TGFB1 mRNA expression was serum- but not hypoxia-inducible.
In contrast, TGF-b3 mRNA expression was hypoxia-inducible, but not serum- inducible
TGFB3 might be a HIF1A target gene
References
em_emtc_emtc_re409( EMT Senescence ):
PMID:11790723
Whereas TGF-b1 and 2 are proscarring growth factors, TGF-b3 is antiscarring
TGF-b1, 2, and 3 are embryonically expressed in skin and up-regulated at adult wound sites
Overlapping expression patterns of HIF-1a and TGF-b3 in vivo
TGF-b1 mRNA expression was serum- but not hypoxia-inducible.
In contrast, TGF-b3 mRNA expression was hypoxia-inducible, but not serum- inducible
Basal TGF-b3 levels were nearly undetectable in HIF-1a ???/??? MEFs, demonstrating that TGF-b3 might be a HIF-1a target gene
PMID:9278421
PMID:10712429
HIF1 target genes include TGFB3
PMID:16887934
VEGF, EG-VEGF, TGFB3 are target genes of HIF1