Phenotype Pyroptosis map
Pyroptosis@Inflammasome platforms

Identifiers
Pyroptosis

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / PYROPTOSIS  map

References
PMID:26885855
PMID:27048821
the amino-terminal gasdermin D
domain may oligomerize to form a membrane pore akin to
how MLKL may act during necroptosis [80, 81]. Alternatively, the pyroptotic gasdermin D domain may induce cell
lysis indirectly by damaging intracellular organelles that
result in disruption of mitochondrial respiration and ATP
synthesis
PMID:27066895
PMID:27984721

Modifications:
In compartment: Inflammasome platforms
  1. Pyroptosis@Inflammasome platforms map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. cleaved~GSDMD@Inflammasome platforms map → map Pyroptosis@Inflammasome platforms map
    2. Pyroptosis@Inflammasome platforms map → map Mitochondrial damage@Mitochondrial Matrix map
    3. Pyroptosis@Inflammasome platforms map → map modulaton of ion fluxes@Inflammasome platforms map
    As Catalyser:
    1. IL1A@Cytosol map → map IL1A@Extracellular space map
    2. HMGB1@Cytosol map → map HMGB1@Extracellular space map