Identifiers
diaphanous homolog 2 (Drosophila)
HUGO:DIAPH2, HGNC:2877, ENTREZ:1730, GENECARDS:GC0XP095939, UNIPROT:O60879
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.