Identifiers
DIA*
diaphanous homolog 1 (Drosophila)
HUGO:DIAPH1, HGNC:2876, ENTREZ:1729, GENECARDS:GC05M140875, UNIPROT:O60610
diaphanous homolog 3 (Drosophila)
HUGO:DIAPH3, HGNC:15480, ENTREZ:81624, GENECARDS:GC13M060239, UNIPROT:Q9NSV4

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

References
em_emtc_emtc_re701( EMT Senescence  ):
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

1. DIA*|​closed@Cytosol

1. DIA*|​closed@Cytosol → DIAPH1@Cytosol
2. DIA*|​closed@Cytosol → DIAPH3@Cytosol
3. em_emtc_emtc_s2905 + DIA*|​closed@Cytosol → em_emtc_emtc_s2920
4. DIA*|​closed@Cytosol → DIAPH2@Cytosol