Protein PIAS1 map

Identifiers
HUGO:PIAS1
Protein inhibitor of activated STAT 1
HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1
DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1"

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10
PMID:20711444

PIAS1@Nucleus

References
su_wnc1_s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
su_wnc1_s_wnc3_re18( Survival  map ):
Order of sumoylation is not important.
PMID:19218564

PIAS1@Nucleus

References
s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
s_wnc3_re18( Survival  map ):
Order of sumoylation is not important.
PMID:19218564

PIAS1@Primary Cilium

References
s_shh1_re76( Survival  map ):
PMID:20711444
PTM=sumoylation N/A in CellDesigner.
Sumoylation not detected on endogenous Gli proteins.
PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PIAS1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. PIAS1@Nucleus map
  2. PIAS1@Nucleus map
In compartment: Primary Cilium
  1. PIAS1@Primary Cilium map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. PPARG@INNATE_IMMUNE_CELL_Cytosol map + SUMO*@INNATE_IMMUNE_CELL_Cytosol map → map PPARG:​SUMO*@INNATE_IMMUNE_CELL_Cytosol map
      2. GLI2-185*|​pho|​active@Primary Cilium map → map GLI2-185*|​S805_unk|​pho|​active@Primary Cilium map
      3. GLI3-190*|​S849_emp|​active@Primary Cilium map → map GLI3-190*|​S849_emp|​S880_unk|​active@Primary Cilium map
      4. su_wca1_s_wca3_s454 → map CTBP*:​KLF8|​K67_unk@Nucleus map
      5. NFAT1*@Nucleus map → map NFAT1*|​unk@Nucleus map
      6. NFAT1*|​unk@Nucleus map → map NFAT1*|​unk|​unk@Nucleus map
      7. NFAT2*@Nucleus map → map NFAT2*|​K702_unk|​K914_unk@Nucleus map